I scaled back the print scale, now printing the parts of the cat (that’s what that is - a cat part) by 50%, and all the printers have had filament changes, but none have missed there mark after the change like that big one. One printer’s runout sensor did not trigger when the filament ran out, but it has worked subsequently (?).
Homing it was I wanted to do when I saw that it was out of alignment, however I couldn’t figure out how to do that. It seems to me that for making larger prints like this one that take several days that the ability to re-home the machine, or adjust it’s offset, mid-way through the print would be something useful.